منابع مشابه
Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development.
A vexing problem for clinicians in the management of children and adults with congenital heart disease is the management of the accompanying arrhythmias. In the recent decade, the mutational spectrum associated with human congenital heart disease has begun to come into focus.1 The number of distinct genes implicated in human congenital heart disease is considerable, and a large portion of mutat...
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Migration of neurons during cortical development is often assumed to rely on purely post-proliferative reelin signaling. However, Notch signaling, long known to regulate neural precursor formation and maintenance, is required for the effects of reelin on neuronal migration. Here, we show that reelin gain-of-function causes a higher expression of Notch target genes in radial glia and accelerates...
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The structure of ecological communities reflects a tension among forces that alter populations. Marine ecologists previously emphasized control by locally operating forces (predation, competition, and disturbance), but newer studies suggest that inputs from large-scale oceanographically modulated subsidies (nutrients, particulates, and propagules) can strongly influence community structure and ...
متن کاملTbx18 function in epicardial development.
AIMS The embryonic epicardium is a source of smooth muscle cells and fibroblasts of the coronary vasculature and of the myocardium, but the molecular circuits that direct the temporal and spatial generation of these cell types from epicardium-derived cells are only partly known. We aimed to elucidate the functional significance of the conserved epicardial expression of the T-box transcription f...
متن کاملDegrees of Development – How Geographic Latitude Sets the Pace of Industrialization and Demographic Change
Successful economic development is usually characterized by two salient phenomena: industrialization and demographic transition. Chronologically both events happen so closely to each other that historians and economists alike suspect that they are interrelated. This paper develops a theory for their interaction with a special emphasis on the different pattern and pace of transition in cross-cou...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2018
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp277180